Surgery for obesity and weight-related diseases alters the adiponectin/leptin ratio in women with severe obesity and the metabolic syndrome: a randomized controlled trial Thesis by Sandra Maria Belmonte Pereira. Advisor: Luis Vicente Franco de Oliveira and Wilson Rodrigues de Freitas Junior

In recent years, obesity has become a growing and worrying public health problem worldwide, with an increased risk of chronic and aggressive conditions, such as respiratory complications, systemic arterial hypertension, type 2 diabetes mellitus, sleep disorders, cardiovascular and cancer. Bariatric surgery results in excellent weight loss results and reduced comorbidities associated with severe obesity compared to nonsurgical interventions. The objectives of this study are to characterize the biochemical markers total cholesterol, LDL, HDL, total non-HDL cholesterol, glucose and to verify the circulating levels of adiponectin and leptin in blood samples of women with severe obesity and with metabolic syndrome before and after performing the bypass. Roux-en-Y gastric This is a randomized controlled clinical trial involving female patients with a clinical diagnosis of severe obesity and metabolic syndrome with indication for bariatric surgery, recruited from the Obesity Surgery Outpatient Clinic of the Irmandade da Santa Casa de Misericórdia de São Paulo in January. to December 2019. The study design followed the standards of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and the ethical standards established in the Regulatory Guidelines and Norms for Research Involving Human Subjects of the Ministry of Health, RESOLUTION No. 466, of 12 December 2012. Participated in this study, female patients, severely obese and with MS with surgical indication, previous clinical diagnosis based on clinical and laboratory tests, on the waiting list for bariatric surgery according to the indication criteria of the Federal Council of Medicine. Clinically stable participants were consecutively recruited from the Surgery Unit of Santa Casa de Misericórdia de São Paulo and selected according to the eligibility criteria established by the study protocol. Patients were examined preoperatively and at six months after bariatric surgery. According to the data obtained in this study, it can be concluded that weight loss induced by bariatric surgery in female patients, severely obese and with metabolic syndrome, significantly improved clinical, anthropometric, blood biochemistry and systemic inflammatory profile verified through the ratio of adiponectin to leptin.

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