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Retrospective study for the epidemiological assessment, treatment, evolution and survival of soft tissue sarcomas treated by the Orthopedic Oncology Clinic at Santa Casa de São Paulo, from 2006 to 2019. Data from a total of 121 patients were analyzed according to age, sex, histological type, tumor location, treatment, previous surgery in a non-specialized service, local recurrences, pulmonary metastases and survival analysis. We conclude that STS can occur at any age and the prevalence of the histological type depends on the age group of patients. The most frequent location is on the thigh. Patients who undergo surgery with a non-specialized group have higher rates of local recurrence. Patients with pulmonary metastasis have a lower survival rate.